Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary resection for metastatic nonosteogenic sarcoma.

E T Creagan, T R Fleming, J H Edmonson

    Cancer
    |November 1, 1979
    PubMed
    Summary

    Surgical resection of non-osteogenic sarcoma lung metastases via thoracotomy shows limited 5-year survival (29%). Prognosis is poor for patients with short disease-free intervals or extrathoracic recurrences.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phase II Trial of Dolastatin-10, a Novel Anti-Tubulin Agent, in Metastatic Soft Tissue Sarcomas.

    Sarcoma·2008
    Same author

    Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas.

    Gene therapy·2005
    Same author

    Long-term results of a phase I/II study of high-dose thoracic radiotherapy with concomitant cisplatin and etoposide in limited stage small-cell lung cancer.

    American journal of clinical oncology·2002
    Same author

    Comparison of conventional dose and double dose carboplatin in patients receiving cyclophosphamide plus carboplatin for advanced ovarian carcinoma: a North Central Cancer Treatment Group Study.

    Cancer investigation·2001
    Same author

    Are we there yet?

    Gynecologic oncology·2000
    Same author

    Calcified left ventricular mass: unusual clinical, echocardiographic, and computed tomographic findings of primary cardiac osteosarcoma.

    Mayo Clinic proceedings·2000

    Area of Science:

    • Oncology
    • Thoracic Surgery
    • Sarcoma Research

    Background:

    • Metastatic non-osteogenic sarcoma to the lungs presents a significant therapeutic challenge.
    • Surgical resection via thoracotomy has been a treatment option for these patients.

    Purpose of the Study:

    • To evaluate the long-term efficacy and trends in post-thoracotomy survival for patients undergoing resection of pulmonary metastatic non-osteogenic sarcoma.
    • To identify prognostic factors influencing survival after thoracotomy for lung metastases.

    Main Methods:

    • Retrospective analysis of 112 patients who underwent pulmonary nodule resection for non-osteogenic sarcoma between 1950 and 1976.
    • Survival rates and prognostic factors were analyzed.

    Main Results:

    • The 5-year post-thoracotomy survival rate was 29%, with a median survival of 18 months.
    • No significant improvement in survival was observed between 1950 and 1976.
    • Shorter pre-thoracotomy disease-free intervals (<12 months) and extrathoracic recurrences were associated with a poorer prognosis (p < 0.01 and p = 0.01, respectively).
    • Age, sex, histology, number of excised lesions, and lesion site did not significantly impact survival.

    Conclusions:

    • The therapeutic value of thoracotomy for metastatic non-osteogenic sarcoma has remained unchanged over the past 25 years.
    • The current data do not definitively support the increasing use of thoracotomy for this condition.

    Related Experiment Videos