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Junctional membrane permeability: restoration by repolarizing current.

B Rose

    Science (New York, N.Y.)
    |August 7, 1970
    PubMed
    Summary
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    Electrical currents can restore cell membrane function in Chironomus salivary glands. Inward currents applied to nonjunctional membranes reverse chemical damage to junctional membrane conductance.

    Area of Science:

    • Cell biology
    • Biophysics
    • Physiology

    Background:

    • Junctional membrane conductance is crucial for cell-to-cell communication.
    • Chemical treatments can disrupt normal cell function, including membrane conductance.
    • Chironomus salivary glands serve as a model system for studying cellular processes.

    Purpose of the Study:

    • To investigate the effect of electrical currents on junctional membrane conductance.
    • To determine if inward currents can restore conductance depressed by chemical treatments.
    • To elucidate the mechanisms underlying membrane potential regulation in salivary gland cells.

    Main Methods:

    • Utilized electrophysiological techniques to measure junctional membrane conductance.
    • Applied specific chemical treatments to depress conductance.

    Related Experiment Videos

  • Passed inward electrical currents through nonjunctional cell membranes.
  • Monitored changes in junctional membrane conductance in response to current application.

    • Main Results:

    • Chemical treatments significantly reduced junctional membrane conductance.
    • Inward currents applied to nonjunctional membranes effectively restored conductance.
    • The restoration of conductance was dose-dependent on the applied current.
    • These findings suggest a direct link between membrane potential and junctional conductance.

    Conclusions:

    • Electrical stimulation via nonjunctional membranes can reverse chemical-induced damage to junctional membranes.
    • This study highlights the potential for electrical interventions to restore cellular function.
    • The results provide insights into the electrophysiological properties of Chironomus salivary gland cells.