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Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
Published on: July 28, 2009
Prolactin localization in the primate pituitary by immunofluorescence
Science (New York, N.Y.)
|July 24, 1970
Summary
Researchers distinguished prolactin cells from growth hormone cells in monkey pituitary glands using histologic and antibody methods. This confirms prolactin is immunochemically distinct from growth hormone in primates and other mammals.
Area of Science:
- Endocrinology
- Cell Biology
- Immunohistochemistry
Background:
- The pituitary gland produces crucial hormones like prolactin and growth hormone.
- Distinguishing between hormone-producing cells is vital for understanding pituitary function.
Purpose of the Study:
- To differentiate cells containing prolactin from those containing growth hormone in adult monkey pituitary glands.
- To confirm the immunochemical distinctness of prolactin and growth hormone in primates.
Main Methods:
- Histologic techniques were employed to examine pituitary tissue structure.
- Fluorescent antibody techniques were utilized for specific protein localization.
Main Results:
- Cells containing prolactin were clearly identified and separated from cells containing growth hormone.
- The study demonstrated a clear immunochemical distinction between prolactin and growth hormone.
Conclusions:
- Prolactin and growth hormone reside in distinct cell populations within the primate pituitary gland.
- These findings support the immunochemical distinguishability of prolactin from growth hormone across mammalian species.
