Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

1.2K
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
1.2K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

1.0K
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
1.0K
Peptic Ulcer01:27

Peptic Ulcer

48
Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
48
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

28
Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
28
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

44
Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...
44
Peptic Ulcer Disease III: Clinical Manifestations and Complications01:25

Peptic Ulcer Disease III: Clinical Manifestations and Complications

38
Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Otolith elemental fingerprints indicate the importance of estuarine nursery areas for European anchovy in the Gulf of Cadiz.

Marine environmental research·2026
Same author

Re: comment on: Miedany et al. response letter: Beyond the symptoms: personalizing giant cell arteritis care through multidimensional patient reported outcome measure. Volume 75, December 2025, 152844.

Seminars in arthritis and rheumatism·2026
Same author

Comment on: Miedany et al. Beyond the symptoms: Personalizing giant cell arteritis care through multidimensional patient reported outcome measure.

Seminars in arthritis and rheumatism·2025
Same author

Sketch of Burmah and Medical Science among the Burmese.

Western journal of medicine and surgery·2024
Same author

Sketch of Burmah and Medical Science among the Burmese.

Medical examiner (Philadelphia, Pa.)·2023
Same author

Impact of enhanced personal protective equipment on safety and logistics of pre-hospital emergency anaesthesia during the COVID-19 pandemic: a retrospective crossover study.

British journal of anaesthesia·2022

Related Experiment Video

Updated: May 3, 2026

Laparoscopic Pancreatoduodenectomy With Modified Blumgart Pancreaticojejunostomy
08:57

Laparoscopic Pancreatoduodenectomy With Modified Blumgart Pancreaticojejunostomy

Published on: June 17, 2018

16.9K

Giant duodenal ulcer.

K Lumsden, J C MacLarnon, J Dawson

    Gut
    |July 1, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Giant duodenal ulcers, larger than 2cm, commonly cause hemorrhage and abdominal pain. Diagnosis can be challenging, leading to potential misidentification, despite a falling mortality rate.

    More Related Videos

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
    03:37

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

    Published on: December 20, 2024

    1.0K
    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
    10:10

    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

    Published on: April 17, 2026

    200

    Related Experiment Videos

    Last Updated: May 3, 2026

    Laparoscopic Pancreatoduodenectomy With Modified Blumgart Pancreaticojejunostomy
    08:57

    Laparoscopic Pancreatoduodenectomy With Modified Blumgart Pancreaticojejunostomy

    Published on: June 17, 2018

    16.9K
    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
    03:37

    Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

    Published on: December 20, 2024

    1.0K
    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
    10:10

    Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms

    Published on: April 17, 2026

    200

    Area of Science:

    • Gastroenterology
    • Radiology
    • Internal Medicine

    Background:

    • Benign giant duodenal ulcers are rare but serious conditions.
    • These ulcers present unique diagnostic challenges.
    • Hemorrhage is a frequent complication.

    Purpose of the Study:

    • To analyze the clinical presentation and radiological findings of benign giant duodenal ulcers.
    • To highlight diagnostic pitfalls associated with these lesions.
    • To discuss optimal management strategies for affected patients.

    Main Methods:

    • Retrospective analysis of 25 cases of benign giant duodenal ulcers.
    • Barium meal examinations were used to identify ulcer craters (≥2 cm).
    • Clinical symptoms, radiological appearances, and outcomes were reviewed.

    Main Results:

    • Abdominal pain was the most common symptom, though not always typical of chronic peptic ulcer.
    • Hemorrhage occurred in a significant majority of patients.
    • Radiological misdiagnosis, mistaking ulcers for the duodenal cap, was noted.

    Conclusions:

    • Benign giant duodenal ulcers require careful radiological assessment to avoid misdiagnosis.
    • Despite falling rates, the mortality associated with these ulcers remains high.
    • Effective management protocols are crucial for improving patient outcomes.