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Related Experiment Videos

Insulin levels in primates by immunoassay.

G V Mann, O B Crofford

    Science (New York, N.Y.)
    |September 25, 1970
    PubMed
    Summary

    New World primates like Cebus and Saimiri have minimal insulin, unlike Old World primates such as rhesus and chimpanzees, which show human-like insulin levels. These findings indicate significant structural variations in primate insulins.

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    Area of Science:

    • Comparative endocrinology
    • Primate biology
    • Immunology

    Background:

    • Insulin is a crucial hormone regulating blood glucose.
    • Primate insulin structures are generally conserved but may exhibit variations.
    • Immunoassay systems are vital for quantifying hormone levels.

    Purpose of the Study:

    • To compare insulin levels across different primate divisions.
    • To investigate potential structural differences in primate insulin using an immunoassay.

    Main Methods:

    • Utilized an immunoassay system employing guinea pig antibody to pork insulin.
    • Quantified insulin levels in New World primates (Cebus, Saimiri) and Old World primates (rhesus, chimpanzee).

    Main Results:

    • Trace amounts of insulin detected in New World primates (Cebus, Saimiri).
    • Human-like insulin levels identified in Old World primates (rhesus, chimpanzee).

    Conclusions:

    • Significant structural differences exist between New World and Old World primate insulins.
    • Immunoassay results highlight evolutionary divergence in insulin structure.

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