Effects of prostaglandins on coronary flow rate and left ventricular work in isolated rat heart

In isolated rat hearts PGD2, PGE1, PGE2, PGF2 alpha and PGI2 increased coronary flow rate at concentrations of about 23, 1.4, 0.4, 2.5 and 0.6 nmol per l respectively. PGD2, PGE2, and PGI2 did not affect left ventricular work (W 1v). PGE1 (14 nmol/l) lowered W 1v (12% and PGF2 alpha (9 nmol/l) increased W 1v (10%). It is concluded that endogenously released PGI2 can probably affect coronary flow rate.