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LSD and genetic damage.

N I Dishotsky, W D Loughman, R E Mogar

    Science (New York, N.Y.)
    |April 30, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Pure lysergic acid diethylamide (LSD) in moderate doses does not appear to cause chromosome damage or genetic mutations in humans. Studies suggest that observed chromosomal aberrations are more likely linked to general drug abuse rather than LSD itself.

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    Area of Science:

    • Pharmacology and Toxicology
    • Genetics and Molecular Biology
    • Reproductive Health

    Background:

    • Early research suggested lysergic acid diethylamide (LSD) could induce chromosomal breakage and genetic damage.
    • Conflicting in vitro and in vivo study results necessitated a comprehensive review of LSD's genotoxic and teratogenic potential.

    Purpose of the Study:

    • To evaluate the evidence for LSD-induced chromosomal damage, mutagenicity, teratogenicity, and carcinogenicity in humans.
    • To differentiate the effects of pure LSD from those of illicit LSD preparations.

    Main Methods:

    • Systematic review and analysis of in vitro and in vivo chromosomal studies.
    • Examination of data from human subjects exposed to pure and illicit LSD.
    • Review of studies on mutagenicity in drosophila and teratogenicity in animal models.

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    Main Results:

    • In vitro studies showed mixed results, with damage often occurring at unachievable human exposure levels.
    • In vivo studies indicated significantly higher rates of chromosomal aberrations in users of illicit LSD compared to pure LSD.
    • Pure LSD showed weak mutagenic effects only at extremely high doses, not relevant to human use; no significant teratogenic or carcinogenic effects were demonstrated in humans.

    Conclusions:

    • Chromosome damage observed in users is likely associated with general drug abuse, not pure LSD.
    • Pure LSD, in moderate doses, does not appear to cause detectable chromosomal or genetic damage in vivo.
    • Pure LSD is not considered a teratogen or carcinogen in humans, suggesting controlled experimental use is acceptable outside of pregnancy.