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Anomalous urinary proteins in patients with serum M-components
Canadian Medical Association Journal
|April 3, 1971
Summary
Bence Jones proteinuria is common in patients with serum M-components, particularly multiple myeloma. Detecting abnormal urinary proteins aids in diagnosis and prognosis.
Area of Science:
- Nephrology
- Hematology
- Clinical Chemistry
Background:
- Serum M-components are abnormal proteins produced by plasma cells.
- Their presence can indicate various hematologic disorders, including multiple myeloma.
- Urinary protein analysis is crucial for comprehensive patient assessment.
Purpose of the Study:
- To investigate the prevalence of abnormal urinary proteins in patients with serum M-components.
- To correlate urinary protein findings with specific diagnoses and M-component types.
- To assess the diagnostic and prognostic significance of urinary M-components.
Main Methods:
- Analysis of 250 urine specimens from 365 patients with serum M-components.
- Urine concentration followed by electrophoresis and immunoelectrophoresis.
- Quantification and characterization of Bence Jones proteins and other M-components.
Main Results:
- Bence Jones proteinuria detected in 63% of patients overall.
- Higher frequency in multiple myeloma (71%), especially IgD myeloma and light chain disease (100%).
- Other M-components found in 18% of patients, varying by condition.
Conclusions:
- Abnormal urinary proteins, especially Bence Jones proteinuria, are frequent in serum M-component patients.
- Detection aids in diagnosing and determining the prognosis of conditions like multiple myeloma.
- Urinary protein electrophoresis and immunoelectrophoresis are valuable diagnostic tools.
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