Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rhesus isoimmunization after abortion.

S Murray, S L Barron

    British Medical Journal
    |July 10, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Rh-negative women undergoing abortion face a 9.4% risk of developing Rh antibodies. Prophylactic anti-D immunoglobulin is recommended, potentially at a lower dose than 75 mcg, as the Kleihauer test is not predictive.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cultivating a resilient future workforce.

    British dental journal·2025
    Same author

    Laser beam pointing stabilization using analog position-sensitive diodes.

    The Review of scientific instruments·2025
    Same author

    Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

    Physical review letters·2025
    Same author

    First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

    Physical review letters·2025
    Same author

    Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

    Physical review letters·2025
    Same author

    Measurements of Chemical Potentials in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

    Physical review letters·2024
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Area of Science:

    • Immunology
    • Obstetrics & Gynecology
    • Transfusion Medicine

    Background:

    • Rh(D)-negative status in pregnant individuals poses a risk for hemolytic disease of the newborn.
    • Abortion, whether spontaneous or therapeutic, can lead to Rh isoimmunization in Rh(D)-negative women.
    • Current recommendations include prophylactic anti-D immunoglobulin for Rh(D)-negative non-immunized patients undergoing abortion.

    Purpose of the Study:

    • To determine the incidence of Rh antibody development after abortion in Rh(D)-negative patients.
    • To evaluate the efficacy of the Kleihauer test in predicting isoimmunization risk.
    • To inform optimal dosing strategies for anti-D immunoglobulin prophylaxis.

    Main Methods:

    • Study population: 177 Rh(D)-negative patients.

    Related Experiment Videos

  • Follow-up: 96 patients after spontaneous or therapeutic abortion.
  • Detection methods: Indirect Coombs test and enzyme technique for Rh antibodies.
  • Risk prediction: Kleihauer test evaluation.

    • Main Results:

    • Overall incidence of Rh antibody development was 9.4% (9 out of 96 followed-up patients).
    • Antibodies were detected by indirect Coombs test in 2 patients and by enzyme technique in 7 patients.
    • The Kleihauer test showed no value in predicting the risk of isoimmunization.

    Conclusions:

    • Abortion presents a significant risk of Rh isoimmunization in Rh(D)-negative women.
    • Prophylactic anti-D immunoglobulin is crucial for Rh(D)-negative non-immunized patients post-abortion.
    • Lower doses of anti-D immunoglobulin may be sufficient, and the Kleihauer test is not a reliable predictor of risk.