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Related Experiment Videos

Hemolytic anemia caused by auto anti-N.

V E Dube, R F House, J Moulds

    American Journal of Clinical Pathology
    |June 1, 1975
    PubMed
    Summary

    This study details a rare case of hemolytic anemia in a child, caused by auto anti-N antibodies. The antibody was identified as immunoglobulin G (IgG) through specific laboratory tests.

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    Area of Science:

    • Immunology
    • Hematology
    • Pediatrics

    Background:

    • Hemolytic anemia can be caused by autoantibodies.
    • Auto anti-N antibodies are a rare cause of hemolytic anemia.

    Purpose of the Study:

    • To describe the second reported case of hemolytic anemia attributed to auto anti-N antibodies.
    • To characterize the nature of the auto anti-N antibody involved.

    Main Methods:

    • Case report of a 7-year-old boy with hemolytic anemia.
    • Immunological testing including Coombs test with anti-human IgG sera.
    • Biochemical analysis using 2-mercaptoethanol and G-200 Sephadex chromatography.

    Main Results:

    • The patient presented with hemolytic anemia.
    • The causative antibody was identified as immunoglobulin G (IgG).
    • The antibody's IgG nature was confirmed by its resistance to 2-mercaptoethanol and its behavior during chromatographic separation.

    Conclusions:

    • Auto anti-N antibodies can cause hemolytic anemia in children.
    • The antibody in this case was characterized as IgG, providing further insight into its properties.

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