Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on prostaglandin antagonists.

A Bennett, J Posner

    British Journal of Pharmacology
    |August 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Researchers evaluated three prostaglandin antagonists for blocking PGE(2) and PGF(2alpha) in gastrointestinal muscle. Polyphloretin phosphate showed selective antagonism in human and guinea-pig tissues, while another compound was selective for rat and guinea-pig tissues.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interferon-tau concentration at the vaginal fornix and cervical ostium predicted early pregnancy outcomes in lactating dairy cows†.

    Biology of reproduction·2025
    Same author

    Prevalence, incidence, and progression of hip osteoarthritis in a young military population: The ADVANCE cohort study.

    Osteoarthritis and cartilage open·2025
    Same author

    Evaluation of the current use of MRI to aid the diagnosis of axial spondyloarthritis in the UK: results from a freedom of information request.

    Clinical radiology·2023
    Same author

    Photon spectra in NPL standard monoenergetic neutron fields.

    Radiation protection dosimetry·2023
    Same author

    Development, design and experience of the UK Military's return to diving pathway following SARS-CoV-2 infection.

    BMJ military health·2022
    Same author

    A balancing act: changing the referral pathway following remote consultations for dizziness during the coronavirus disease 2019 pandemic.

    The Journal of laryngology and otology·2022
    Same journal

    Glucagon-like peptide-1 improves vascular endothelial dysfunction in hypertensive mice via CREB-driven transcriptional regulation of long non-coding RNA 155383.

    British journal of pharmacology·2026
    Same journal

    The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling.

    British journal of pharmacology·2026
    Same journal

    Peripheral targets for neuropathic pain.

    British journal of pharmacology·2026
    Same journal

    Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

    British journal of pharmacology·2026
    Same journal

    The role of protein arginine methyltransferases in sickle cell-mediated neurovascular impairments in mice.

    British journal of pharmacology·2026
    Same journal

    β-Cyclodextrin inclusion enhances the pro-resolving effects of the annexin A1 mimetic Ac2-26 in a mouse model of antigen-induced arthritis.

    British journal of pharmacology·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Biochemistry

    Background:

    • Prostaglandins (PGs) are potent mediators of gastrointestinal function.
    • Understanding prostaglandin receptor interactions is crucial for developing therapeutic agents.
    • Selective antagonists are needed to probe specific prostaglandin roles in the gut.

    Purpose of the Study:

    • To evaluate the efficacy of three prostaglandin antagonists in blocking PGE(2) and PGF(2alpha) effects.
    • To determine the selectivity of these antagonists across different species (human, guinea-pig, rat).
    • To assess the potential of these compounds as pharmacological tools for studying prostaglandin receptors.

    Main Methods:

    • In vitro studies using isolated gastrointestinal muscle preparations from human, guinea-pig, and rat.

    Related Experiment Videos

  • Assessment of prostaglandin antagonist activity against exogenously applied PGE(2) and PGF(2alpha).
  • Evaluation of effects on basal muscle tone and potassium-induced contractions.

    • Main Results:

    • 7-oxa-13-Prostynoic acid demonstrated non-selective antagonism or ineffectiveness, with spasmogenic activity in rat fundus.
    • 1-Acetyl-2-(8-chloro-10,11-dihydrodibenz (b,f)(1,4) oxazepine-10-carbonyl) hydrazine selectively antagonized PGs in guinea-pig and rat, but not human muscle.
    • Polyphloretin phosphate selectively antagonized PGs in human and guinea-pig muscle, but stimulated rat fundus.
    • All antagonists reduced muscle tone and potassium-induced contractions; none blocked inhibitory PGE(2) effects on intestinal circular muscle.

    Conclusions:

    • The tested prostaglandin antagonists exhibit varying selectivity and efficacy across species.
    • Polyphloretin phosphate and the acetyl hydrazine derivative show potential for selective antagonism in specific tissues.
    • These findings provide insights into prostaglandin receptor subtypes and the utility of these compounds in pharmacological research.