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Related Experiment Videos

Morphine tolerance and dependence induced by intraventricular injection.

E Eidelberg, C A Barstow

    Science (New York, N.Y.)
    |October 1, 1971
    PubMed
    Summary

    Morphine injections into the brain depressed operant behavior in monkeys. Repeated morphine administration led to tolerance, requiring higher doses, and precipitated withdrawal signs when an antagonist was given, indicating dependence.

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    Brain research·1987

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Opioid drugs like morphine are known for their psychoactive effects.
    • Understanding the central mechanisms of opioid action is crucial for addiction research.

    Purpose of the Study:

    • To investigate the effects of central morphine administration on operant behavior in non-human primates.
    • To assess the development of tolerance and physical dependence following repeated central morphine exposure.

    Main Methods:

    • Monkeys were trained to perform food-reinforced lever pressing.
    • Morphine was administered via the cerebral ventricular system.
    • Dose-response relationships were evaluated, and antagonist-precipitated withdrawal was observed.

    Main Results:

    • Central morphine injections significantly depressed or abolished lever pressing behavior.
    • Repeated administrations resulted in dose-dependent tolerance, necessitating increased morphine doses for the same effect.
    • Administration of an opioid antagonist precipitated clear signs of abstinence, confirming physical dependence.

    Conclusions:

    • The cerebral ventricular system is a sensitive site for morphine's behavioral effects.
    • Central administration of morphine can induce tolerance and physical dependence in primates.
    • These findings contribute to understanding the neurobiological basis of opioid addiction and dependence.

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