Thymidylate synthetase and its relationship to dihydrofolate reductase

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy.

Annals of the New York Academy of Sciences·2026

Loneliness Biases Social Engagement Decisions: Evidence From Value-Based Choice Models.

Annals of the New York Academy of Sciences·2026

Urban Climate Risk Governance and Corporate Energy Intensity: Evidence From China's Climate Adaptation City Pilots.

Annals of the New York Academy of Sciences·2026

Genetic Adaptation Accompanying the Emergence of Inkoo Virus, the European Orthobunyavirus jamestownense.

Annals of the New York Academy of Sciences·2026

Neurotechnological Natives and the Neurotechnology Shift: A Research Agenda for the Brain-as-Interface Era.

Annals of the New York Academy of Sciences·2026

Baseline Fatty Acids and Time-Averaged Executive Function in Ugandan Children With Perinatal HIV.

Annals of the New York Academy of Sciences·2026

New insight of congenital uterine anomalies on pregnancy outcomes: a retrospective study based on PGT-A.

Reproductive biomedicine online·2026

Impact of combining fast vitrification and fast warming protocols on live birth outcomes.

Reproductive biomedicine online·2026

Tranexamic acid and its use in early pregnancy; a scoping review.

Thrombosis research·2026

Associations Between Different Subtypes of Adverse Childhood Experiences with Reproductive Mood Disorders-a Scoping Review.

Current psychiatry reports·2026

Fetal cardiac rhabdomyoma: Two prenatally diagnosed cases with contrasting outcomes.

Radiology case reports·2026

A partially duplicated left ovarian vein bisected by the left renal artery: Hypothesized embryologic origins and clinical implications.

Urology case reports·2026

Related Experiment Videos

Thymidylate synthetase and its relationship to dihydrofolate reductase

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy.

Loneliness Biases Social Engagement Decisions: Evidence From Value-Based Choice Models.

Urban Climate Risk Governance and Corporate Energy Intensity: Evidence From China's Climate Adaptation City Pilots.

Genetic Adaptation Accompanying the Emergence of Inkoo Virus, the European Orthobunyavirus jamestownense.

Neurotechnological Natives and the Neurotechnology Shift: A Research Agenda for the Brain-as-Interface Era.

Baseline Fatty Acids and Time-Averaged Executive Function in Ugandan Children With Perinatal HIV.

New insight of congenital uterine anomalies on pregnancy outcomes: a retrospective study based on PGT-A.

Impact of combining fast vitrification and fast warming protocols on live birth outcomes.

Tranexamic acid and its use in early pregnancy; a scoping review.

Associations Between Different Subtypes of Adverse Childhood Experiences with Reproductive Mood Disorders-a Scoping Review.

Fetal cardiac rhabdomyoma: Two prenatally diagnosed cases with contrasting outcomes.

A partially duplicated left ovarian vein bisected by the left renal artery: Hypothesized embryologic origins and clinical implications.

Related Experiment Videos

Thymidylate synthetase and its relationship to dihydrofolate reductase

Related Concept Videos

Related Articles