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Interlaboratory comparison of behavioral testing.

R E Butcher, R M Hoar, G A Nolan

    Journal - Association of Official Analytical Chemists
    |July 1, 1979
    PubMed
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    This study assessed the reliability of behavioral tests for psychotoxic potential. Despite variations, a standard for interlaboratory reliability in behavioral testing is achievable.

    Area of Science:

    • Neuroscience
    • Toxicology
    • Behavioral Science

    Background:

    • Regulatory agencies increasingly require psychotoxic potential testing for new substances.
    • Assessing the reliability of behavioral tests across different laboratories presents challenges.

    Purpose of the Study:

    • To evaluate the interlaboratory reliability of a standardized maze learning procedure for behavioral testing.
    • To determine if a consistent standard for behavioral testing can be achieved across multiple labs.

    Main Methods:

    • A model animal maze learning procedure was standardized and implemented in three cooperating laboratories.
    • Identical mazes and uniform procedures were used, with both normal control and neurologically impaired rat groups.

    Main Results:

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    • Significant differences in test results were observed among the participating laboratories.
    • Neurologically impaired rats showed significantly higher error rates (mean errors=28.3) compared to normal controls (mean errors=12.7).

    Conclusions:

    • While interlaboratory variations exist, the study demonstrates that a reliable standard for behavioral testing is attainable.
    • Standardization of procedures and controls is crucial for consistent psychotoxic potential assessment.