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Kidney function after methoxyflurane analgesia during labour.

M Rosen, P Latto, A W Asscher

    British Medical Journal
    |January 8, 1972
    PubMed
    Summary
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    Methoxyflurane, used as a self-administered analgesic during childbirth, showed no evidence of kidney damage in mothers. Studies comparing it to nitrous oxide found no significant differences in renal function markers.

    Area of Science:

    • Obstetrics and Gynecology
    • Anesthesiology
    • Nephrology

    Background:

    • Childbirth analgesia is crucial for maternal comfort.
    • Methoxyflurane and nitrous oxide are common analgesic options.
    • Assessing the impact of analgesics on maternal renal function is important.

    Purpose of the Study:

    • To evaluate the potential nephrotoxicity of methoxyflurane when used as a self-administered analgesic in laboring mothers.
    • To compare the effects of methoxyflurane with nitrous oxide/oxygen on maternal renal function markers.

    Main Methods:

    • A study involving 50 mothers compared methoxyflurane (0.35%) with nitrous oxide/oxygen (Entonox) for analgesia.
    • Renal function was assessed by measuring urinary and blood urea concentrations, osmolalities, and packed cell volume before and after delivery.

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  • A larger cohort of 200 mothers (100 per group) had urinary and blood urea concentrations measured upon hospital discharge.

    • Main Results:

    • No evidence of renal dysfunction was observed in either the methoxyflurane or the control (nitrous oxide) group.
    • No significant differences in renal function markers were found between the groups in either study cohort.
    • Specific markers analyzed included urinary and plasma osmolalities, packed cell volume, and urea concentrations.

    Conclusions:

    • Methoxyflurane, when used as a self-administered analgesic during labor, does not appear to cause nephrotoxicity.
    • The study supports the safety of methoxyflurane concerning maternal renal function compared to nitrous oxide analgesia.