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Updated: Aug 12, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
Insights
The apexcardiogram (acg) detects left ventricular dysfunction in heart attack and angina patients. This tool shows earlier changes than ECGs, aiding heart disease diagnosis and monitoring.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- The apexcardiogram (acg) is a non-invasive technique to assess cardiac mechanical function.
- Left ventricular (LV) contractile abnormalities are key indicators in various ischemic heart diseases.
Purpose of the Study:
- To evaluate the apexcardiogram's (acg) utility in reflecting left ventricular (LV) contractile patterns in patients with acute myocardial infarction (AMI), preinfarction angina (PIA), and stable ischemic heart disease (IHD).
- To compare the sensitivity and timing of acg changes versus electrocardiogram (ECG) changes in diagnosing and monitoring these conditions.
Main Methods:
- Serial recording of apexcardiograms (acg) in patients diagnosed with AMI, PIA, and IHD.
- Correlation of acg findings (e.g., systolic wave dyskinesis, 'a' wave amplitude) with clinical presentation and ECG changes.
- Monitoring acg changes over time and post-intervention (nitroglycerine, coronary bypass surgery).
Main Results:
- Abnormal acg patterns, including paradoxical systolic bulging and increased 'a' wave amplitude, were observed in patients with AMI and PIA, often preceding ECG changes.
- Acg abnormalities during angina pain resolved promptly with nitroglycerine.
- Patients with stable IHD showed persistent acg patterns, while those undergoing coronary bypass surgery exhibited immediate postoperative improvement.
- Acg changes were more sensitive and appeared earlier than ECG changes in detecting cardiac dysfunction.
Conclusions:
- The apexcardiogram (acg) effectively reflects left ventricular (LV) contractile patterns, potentially serving as an indirect ventriculogram.
- The acg's enhanced sensitivity and earlier detection of abnormalities make it a valuable diagnostic and monitoring tool for patients with ischemic heart disease.
Abstract:
The apexcardiogram (acg), when recorded serially in patients with acute myocardial infarction (ami), preinfarction angina (pia) and stable ischemic heart disease (ihd), appeared to reflect the abnormal patterns of contraction of the left ventricle in these conditions. Thus, paradoxical bulging (dyskinesis) of the systolic wave or increased "a" wave amplitude with gradual recovery over several weeks was found in all 60 patients with documented ami and in 18 of 20 patients with pia. Electrocardiogram changes were noted, however, in only eight of the pia patients. Changes in the acg frequently antedated ischemia in the ecg. Paradoxical bulging of the systolic wave of the acg was additionally noted in patients during the pain of angina pectoris but this promptly disappeared after the administration of nitroglycerine. Patients with classic angina often had normal resting ecg's but abnormal resting acg's. In contrast to the relatively transient abnormalities noted above, the acg remained unchanged in most patients with stable ihd during follow-up of three months to two years. Patients undergoing coronary bypass operations, however, showed immediate improvement in the acg in the postoperative period. These results suggest the acg reflects the contractile pattern of the left ventricle, and may be an indirectly recorded ventriculogram. Its enhanced sensitivity and the earlier development of changes in comparison to the ecg make this a valuable tool in the study of patients with heart disease.
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