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Microsomal lipid peroxidation: morphological characterization.

A U Arstila, M A Smith, B F Trump

    Science (New York, N.Y.)
    |February 4, 1972
    PubMed
    Summary
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    Lipid peroxidation causes distinct cellular changes in liver and kidney microsomes, including vesicle aggregation and membrane alterations. The fundamental membrane structure remains intact despite significant damage.

    Area of Science:

    • Cellular biology
    • Biochemistry
    • Toxicology

    Background:

    • Lipid peroxidation is a key process in oxidative stress.
    • Microsomes are crucial cellular components involved in metabolism and detoxification.
    • Understanding microsomal damage is vital for studying organ toxicity.

    Purpose of the Study:

    • To characterize the morphological changes in liver and kidney microsomes following lipid peroxidation.
    • To investigate the structural integrity of microsomal membranes after peroxidation.
    • To compare the observed aggregates with known cellular structures.

    Main Methods:

    • Induction of lipid peroxidation in isolated liver and kidney microsomes.
    • Morphological analysis using electron microscopy.

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  • Detailed observation of membrane structure and aggregate formation.

    • Main Results:

    • Lipid peroxidation induced characteristic morphological changes, including ribosome detachment and vesicle aggregation.
    • Aggregates were formed by dense amorphous material and myelin figures.
    • The trilaminar membrane structure was preserved, though spacing increased.

    Conclusions:

    • Lipid peroxidation leads to specific, recognizable ultrastructural alterations in microsomes.
    • The retained membrane integrity suggests a degree of resilience.
    • Observed aggregates share similarities with lipofuscin and endoplasmic reticulum aggregates, aiding in pathological interpretation.