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Delta 9-tetrahydrocannabinol: aversive effects in rat at high doses
Science (New York, N.Y.)
|February 25, 1972
Abstract:
Water-deprived rats were administered a single dose of Delta(9)-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.