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Dermatofibrosarcoma protuberans. An ultrastructural study of five cases.
Journal of Cutaneous Pathology
|August 1, 1979
Summary
Dermatofibrosarcoma protuberans originates from fibroblasts, not nerve cells or fibrous histiocytomas. Ultrastructural analysis confirms the fibroblast as the fundamental cell type in this skin cancer.
Area of Science:
- Dermatopathology
- Oncology
- Cell Biology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer.
- Its cellular origin and relationship to other tumors remain subjects of investigation.
- Understanding DFSP's basic cell is crucial for diagnosis and treatment.
Observation:
- An ultrastructural study examined five cases of dermatofibrosarcoma protuberans.
- The primary cell observed was a spindle-shaped fibroblast with a distinctive, deeply lobulated nucleus.
- Basal lamina material was sparse, and other differential features were absent, precluding perineural or endoneural origin.
Findings:
- The fundamental cell in DFSP is the fibroblast.
- Evidence supporting an origin from perineural or endoneural cells was not found.
- Histiocytic cells were present in one case, but the basic cell remained the fibroblast, refuting a relationship with fibrous histiocytoma.
Implications:
- This study clarifies the cellular origin of dermatofibrosarcoma protuberans.
- Findings aid in differentiating DFSP from other spindle cell tumors.
- Establishes the fibroblast as the key cell type, impacting diagnostic criteria and potentially therapeutic strategies.