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Related Experiment Videos

The specialized junctions between Merkel cell and neurite: an electron microscopic study.

M Mihara, K Hashimoto, K Ueda

    The Journal of Investigative Dermatology
    |November 1, 1979
    PubMed
    Summary

    Electron microscopy revealed specialized nerve junctions innervating mouse sinus hair Merkel cells. These junctions suggest Merkel cells may secrete substances and potentially form reciprocal synapses with afferent neurites.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Histology

    Background:

    • Merkel cells are sensory receptors involved in touch perception.
    • The innervation of sinus hairs and the precise nature of Merkel cell-neurite interactions require further elucidation.

    Purpose of the Study:

    • To investigate the ultrastructure of nerve supply to mouse sinus hair Merkel cells.
    • To characterize the specialized junctions between Merkel cells and associated neurites.

    Main Methods:

    • Electron microscopy was used to examine longitudinal serial sections of mouse sinus hair.
    • Detailed ultrastructural analysis of the outer root sheath and perifollicular regions was performed.

    Main Results:

    • Three neurites exclusively innervating intrafollicular Merkel cells were identified, distinct from tactile nerve endings.

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  • Two types of specialized junctions, desmosome-like and synapse-like, were observed between Merkel cells and neurites.
  • Evidence suggested exocytotic secretion from Merkel cell granules and the potential for reciprocal synapses.

    • Conclusions:

    • Mouse sinus hairs possess a unique innervation pattern targeting Merkel cells.
    • Specialized junctions indicate complex communication, including potential secretion and reciprocal synaptic activity, between Merkel cells and neurites.