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Updated: Aug 10, 2026
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Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
Published on: March 8, 2013
Radionuclide immunoglobulin lymphangiography: a case report
Cancer
|June 1, 1975
Summary
Radioactive iodine (Iodine-131) linked to antibodies targeted a tumor antigen in Hodgkin
Area of Science:
- Oncology
- Immunology
- Nuclear Medicine
Background:
- Hodgkin's disease is a cancer of the lymphatic system.
- Recurrent Hodgkin's disease presents treatment challenges.
- Tumor-associated antigens offer potential targets for therapy.
Purpose of the Study:
- To evaluate the use of Iodine-131-labeled immunospecific gamma globulin for treating recurrent Hodgkin's disease.
- To assess the diagnostic and retention capabilities of this targeted radiopharmaceutical.
Main Methods:
- Rabbits were immunized to produce antibodies against the F antigen, a tumor-associated antigen in Hodgkin's disease.
- These antibodies were labeled with Iodine-131.
- The labeled antibody was infused intralymphatically into a patient with recurrent Hodgkin's disease.
- Rectilinear scanning and external monitoring were used to assess tumor localization and activity retention.
Main Results:
- Rectilinear scanning successfully delineated tumor masses in the inguinofemoral and pelvic regions.
- External monitoring confirmed retention of Iodine-131 activity at the tumor sites for an 8-day period.
Conclusions:
- Iodine-131-labeled immunospecific gamma globulin can be effectively used for intralymphatic infusion in recurrent Hodgkin's disease.
- This targeted approach allows for successful tumor delineation and sustained activity retention at tumor sites, indicating potential therapeutic value.
