Unsymmetrical C-substituted ethylenediamine platinum coordination complexes: synthesis and activity against mouse...

A series of new unsymmetrical C-substituted ethylenediamines was prepared. The substituents included branched chain alkyl, cycloalkyl, and phenyl groups. Twenty-eight new platinum compounds were prepared from these diamines and were tested for activity against leukemia L1210. The cycloalkyl substituted ethylenediamines produced especially active compounds. The phenyl-substituted analogs were generally low in activity. The activity of the complexes was compared to aqueous solubility, organic solubility, and amphipathic character. There was good indication that antitumor activity increased as aqueous solubility and hydrophilic character of the molecules increased.