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Related Experiment Videos

Endothelial lesions after temporary clipping. A comparative study.

B Richling, G Griesmayr, A Lametschwandtner

    Journal of Neurosurgery
    |November 1, 1979
    PubMed
    Summary

    Temporary arterial clipping in rats caused endothelial damage, including platelet adherence. Longer clipping durations significantly increased damage compared to clip force or vessel size.

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    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2010

    Area of Science:

    • Vascular Surgery
    • Histology
    • Biomedical Engineering

    Background:

    • Temporary arterial clipping is a common surgical technique.
    • Understanding its impact on the arterial endothelium is crucial for minimizing complications.

    Purpose of the Study:

    • To investigate the effects of temporary arterial clipping on rat arterial endothelium.
    • To determine the influence of clip force, duration, and vessel diameter on endothelial damage.

    Main Methods:

    • Scanning electron microscopy was used to examine rat arterial endothelium.
    • Heifetz clips with varying forces (20-65 gm) were applied for different durations (10-180 minutes).
    • Three vessel diameter ranges (<1 mm, 1.1-1.3 mm, 1.4-2 mm) were tested.

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    Main Results:

    • Varying degrees of endothelial damage were observed.
    • Damage included endothelium detachment and platelet adherence to subendothelial tissue.
    • Clipping duration was a more significant factor in endothelial damage than clip force.

    Conclusions:

    • Prolonged temporary arterial clipping can lead to significant endothelial injury.
    • Vessel diameter did not appear to influence the extent of endothelial damage.
    • These findings highlight the importance of minimizing clipping duration during surgical procedures.