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Related Experiment Videos

Carboxyhemoglobin elevation after exposure to dichloromethane.

R D Stewart, T N Fisher, M J Hosko

    Science (New York, N.Y.)
    |April 21, 1972
    PubMed
    Summary

    Inhaling dichloromethane vapor quickly creates carbon monoxide in humans. This suggests carbon monoxide may be a dichloromethane metabolite, potentially exceeding safe limits even at low exposures.

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    Area of Science:

    • Toxicology
    • Environmental Health
    • Occupational Medicine

    Background:

    • Dichloromethane (DCM) is a widely used industrial solvent.
    • Potential health risks associated with DCM exposure are a significant concern.
    • The metabolic fate of DCM in the human body requires further elucidation.

    Purpose of the Study:

    • To investigate the potential for carbon monoxide (CO) formation in human subjects following DCM inhalation.
    • To determine if CO is a metabolite of DCM.
    • To assess CO levels in relation to established industrial threshold limit values (TLVs) for DCM.

    Main Methods:

    • Human subjects were exposed to controlled concentrations of DCM vapor (500-1000 ppm) for 1-2 hours.
    • Carbon monoxide levels in subjects were monitored during and after exposure.

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  • Analysis focused on the correlation between DCM exposure and CO production.

    • Main Results:

    • Inhalation of DCM at 500-1000 ppm rapidly induced significant carbon monoxide formation in all subjects.
    • The results strongly indicate that carbon monoxide is a metabolite of dichloromethane.
    • CO levels generated could exceed permissible exposure limits, even at DCM concentrations below current TLVs.

    Conclusions:

    • Dichloromethane exposure can lead to the endogenous production of carbon monoxide in humans.
    • Occupational exposure to DCM may pose a risk of exceeding safe carbon monoxide limits.
    • Further research and potential revision of TLVs for DCM may be warranted based on these findings.