[Duration of biological activity of pindolol in uremics (author's transl)]

The duration of biological activity of pindolol following short and long term application was tested using a modified isoproterenol-sensitivity-test. Following a single dose of pindolol the beta-blocking activity in uremics was increased to twice the activity seen in normal controls. Following daily oral application of 10 mg Pindolol over a number of weeks the beta-blockade observed in patients with chronic renal failure was significantly stronger and the duration of action was 6 times longer than in normal controls.