This review of follicular lesions found them to be benign, commonly occurring in the thorax. Symptomatic cases, though rare, show distinct histological differences and resolve after tumor removal.
Area of Science:
Surgical Pathology
Dermatopathology
Oncology
Background:
Follicular lesions are uncommon and can occur in various body sites.
Understanding their histological characteristics is crucial for diagnosis and management.
Purpose of the Study:
To review personally observed cases and existing literature on a specific type of follicular lesion.
To characterize the clinical presentation, common locations, and histological features of these lesions.
Main Methods:
Review of six personally observed cases.
Comprehensive literature search and analysis of 134 previously reported cases.
Histopathological examination of lesion samples.
Main Results:
The lesion is most common in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%).
Ninety percent of cases are asymptomatic or present with pressure symptoms; 10% exhibit systemic signs (fever, elevated ESR, anemia).
Microscopically, lesions feature follicles with thick-walled arteries instead of germinal centers, increased vascularity, and absent sinuses. Symptomatic cases show reaction centers and plasma cell/eosinophil collections.
Conclusions:
All reported cases of this follicular lesion have been benign.
Symptomatic cases exhibit distinct histological features and are curable by tumor removal.
Further research into the pathogenesis and specific subtypes of these follicular lesions is warranted.
