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Salicylate: a structure-activity study of its effects on membrane permeability
Science (New York, N.Y.)
|June 30, 1972
Abstract:
Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.