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Electrophysiological Measurements and Analysis of Nociception in Human Infants
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Perinatal naloxone: when does naloxone affect hyperalgesia?

H Monder, N Yasukawa, J J Christian

    Pharmacology, Biochemistry, and Behavior
    |August 1, 1979
    PubMed

    Pregnant mice were treated with naloxone via subcutaneous implants, from about 5 days prior to parturition. At birth entire litters were cross-fostered so that groups of offspring were exposed to naloxone treated mothers; before birth, after birth to weaning, from about 5 days prior to birth to weaning, or not exposed to naloxone. When tested on a hot-plate at 50 days of age, females either prenatally treated or treated pre- and postnatally showed hyperalgesia to heat. For males, this effect was not evident. This sex difference may have been induced by the cross-fostering procedure.

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