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Coeliactomy: differential toxiphobia conditioning with apomorphine and copper sulfate
Pharmacology, Biochemistry, and Behavior
|September 1, 1979
Summary
Coeliac ganglionectomy in rats reduced the intake of a novel fluid when visceral toxicosis was induced by gastric irritation. However, this effect was not observed with centrally acting emetics, suggesting partial denervation of visceral signals.
Area of Science:
- Neuroscience
- Gastroenterology
- Physiology
Background:
- The coeliac ganglion plays a role in visceral afferent signaling.
- Understanding visceral toxicosis pathways is crucial for gastrointestinal research.
Purpose of the Study:
- To investigate the role of the coeliac ganglion in transmitting signals related to visceral toxicosis.
- To determine if coeliac ganglionectomy affects the intake of a novel fluid in response to emetic challenges.
Main Methods:
- Rats underwent either coeliac ganglionectomy or sham operations.
- Rats were presented with a novel fluid and subsequently received intragastric saline, copper sulfate, or apomorphine.
- Fluid intake was measured after each treatment.
Main Results:
- Coeliac ganglionectomized rats consumed less novel fluid than sham rats after copper sulfate administration.
- Fluid intake was comparable between groups after saline injection.
- Fluid intake was also comparable between groups after apomorphine administration.
Conclusions:
- Coeliac ganglionectomy partially disrupts the afferent nerves transmitting visceral toxicosis signals from the gastric mucosa to the brain.
- The coeliac ganglion is involved in mediating responses to peripherally induced visceral discomfort but not centrally induced emesis.