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Genetic determination of phenotypic variation in sickle cell trait

W E Nance, J Grove

    Science (New York, N.Y.)
    |August 25, 1972
    PubMed

    Abstract:

    Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.

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