Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood microcirculation in the lymph node during the primary immune response.

P G Herman, I Yamamoto, H Z Mellins

    The Journal of Experimental Medicine
    |October 1, 1972
    PubMed
    Summary

    Lymph node vascularity changes significantly after antigenic stimulus, with capillary redistribution and increased density observed. These microvascular alterations may enhance immune cell and fluid exchange within the lymph node.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Congenital duodenal obstruction; roentgen diagnosis by insufflation of air.

    American journal of diseases of children (1911)·2010
    Same author

    Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice.

    Research communications in chemical pathology and pharmacology·1992
    Same author

    Suppression of 125I-uptake in mouse thyroid by seaweed feeding: possible preventative effect of dietary seaweed on internal radiation injury of the thyroid by radioactive iodine.

    The Kitasato archives of experimental medicine·1992
    Same author

    Comparison of ascorbic acid and ascorbic acid 2-O-alpha-glucoside on the cytotoxicity and bioavailability to low density cultures of fibroblasts.

    Biochemical pharmacology·1992
    Same author

    Presence of amelanotic melanocytes within the outer root sheath in senile white hair.

    The Journal of investigative dermatology·1992
    Same author

    Mouse hepatic microsomal oxidation of aliphatic aldehydes (C8 to C11) to carboxylic acids.

    Biochemical and biophysical research communications·1992

    Area of Science:

    • Immunology
    • Vascular Biology
    • Lymphatic System Research

    Background:

    • Lymph nodes are critical for immune responses.
    • Understanding lymph node microvasculature dynamics is key to immune function.
    • Previous studies lacked detailed microangiographic insights into lymph node vascular changes.

    Purpose of the Study:

    • To visualize and characterize lymph node microvascular changes following antigenic stimulus.
    • To investigate the temporal dynamics of capillary and venule alterations.
    • To explore the potential role of high endothelial venules (HE venules) in immune responses.

    Main Methods:

    • Microangiography with contrast material for complete vascular visualization.
    • Histological examination to identify specific microvascular structures.

    Related Experiment Videos

  • Observation of changes over a 15-day period post-antigenic stimulus.

    • Main Results:

    • Complete visualization of lymph node vascular structures achieved.
    • Capillary redistribution and uniform vascularization of cortical lymphoid tissue observed starting day 2.
    • Significant increase in subcapsular and medullary cord capillary diameter and density from day 2 to day 5.
    • Microvasculature returned to normal appearance by day 15.
    • Postcapillary venules, including high endothelial venules (HE venules), widely distributed with individual variations.

    Conclusions:

    • Antigenic stimulus induces significant, dynamic microvascular changes in lymph nodes.
    • Increased vascularity and altered capillary distribution likely facilitate immune cell and fluid exchange.
    • The role and variability of HE venules warrant further investigation in immune responses.