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Related Experiment Videos

Human prolactin: 24-hour pattern with increased release during sleep.

J F Sassin, A G Frantz, E D Weitzman

    Science (New York, N.Y.)
    |September 29, 1972
    PubMed
    Summary

    Human prolactin levels show significant diurnal variation, peaking during sleep. These findings highlight the importance of sleep-wake cycles in regulating prolactin release throughout the day.

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    Area of Science:

    • Endocrinology
    • Neuroscience
    • Sleep Medicine

    Background:

    • Prolactin is a key hormone involved in reproduction and other physiological processes.
    • Understanding prolactin secretion patterns is crucial for diagnosing and treating various endocrine disorders.

    Purpose of the Study:

    • To investigate the diurnal variation of human prolactin secretion.
    • To correlate prolactin levels with sleep-wake cycles.

    Main Methods:

    • Plasma prolactin concentrations were measured using radioimmunoassay.
    • Blood samples were collected every 20 minutes over a 24-hour period.
    • Sleep-wake cycles were monitored polygraphically in six healthy adults.

    Main Results:

    • A distinct diurnal variation in plasma prolactin was observed.
    • Highest prolactin concentrations were recorded during sleep periods.
    • Episodic prolactin release occurred throughout the 24-hour monitoring period.

    Conclusions:

    • Human prolactin secretion is strongly influenced by the sleep-wake cycle.
    • Sleep is a critical period for elevated prolactin release.
    • Further research can explore the neuroendocrine mechanisms underlying these prolactin patterns.

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