North American blastomycosis in Central Canada. A review of 36 cases

Experience with 36 cases of North American blastomycosis in Central Canada is reported. Symptoms referable to the respiratory tract predominated, but no uniform clinical pattern for the disease process was evident. Cutaneous and genitourinary tract involvement was present in only a small proportion of patients. The majority of the patients resided in rural areas or were associated with some form of outdoor occupation or activity. No characteristic radiologic appearance could be identified in this series. Amphotericin B administered intravenously is the treatment of choice for this condition. North American blastomycosis is more widespread on this continent than has been previously demonstrated.