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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

Neonatal bacteriuria: a prospective study in 1,460 infants

G D Abbott

    British Medical Journal
    |January 29, 1972
    PubMed

    Insights

    Bacteriuria (bacteria in urine) affects 1% of newborns. Many asymptomatic cases resolve without antibiotic treatment, but vesicoureteric reflux is common in affected infants.

    Area of Science:

    • Pediatrics
    • Nephrology
    • Infectious Diseases

    Background:

    • Bacteriuria in neonates is uncommon but can indicate serious underlying issues.
    • Early detection and management are crucial for preventing long-term complications.

    Purpose of the Study:

    • To determine the incidence and clinical significance of bacteriuria in a neonatal population.
    • To evaluate the outcomes of symptomatic and asymptomatic bacteriuria in infants.

    Main Methods:

    • Prospective study of 1,460 neonates.
    • Bacteriuria diagnosed via bladder puncture.
    • Clinical assessment, urine analysis, blood tests, intravenous pyelogram, and micturating cystourethrography.

    Main Results:

    • 14 neonates (1%) had bacteriuria; 11 boys, 3 girls.
    • 5 symptomatic infants received antibiotics; 9 asymptomatic infants were observed (5 cleared spontaneously, 4 treated).
    • 8 infants had vesicoureteric reflux; intravenous pyelogram was normal in all.

    Conclusions:

    • Neonatal bacteriuria is infrequent, with a significant proportion of asymptomatic cases resolving spontaneously.
    • Vesicoureteric reflux is a common finding in neonates with bacteriuria, necessitating further investigation.

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