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[Intestinal resorption with 3H labeled enzyme mixture (wobenzyme)]
Acta Medica Austriaca
|January 1, 1979
Summary
Oral administration of a radiolabeled enzyme mixture (Wobenzym) in guinea pigs demonstrated significant absorption from the intestine. The enzymes were detected in plasma, urine, and various organs, indicating systemic distribution.
Area of Science:
- Pharmacokinetics
- Biochemistry
- Enzyme activity
Background:
- Enzyme mixtures are used therapeutically.
- Understanding the absorption and distribution of oral enzyme preparations is crucial for efficacy.
Purpose of the Study:
- To investigate the absorption and systemic distribution of an oral enzyme mixture (Wobenzym) in vivo.
- To determine the bioavailability of enzymes after oral administration.
Main Methods:
- Oral administration of 3H-acetic anhydride labeled Wobenzym to guinea pigs.
- Measurement of radioactivity in various tissues (intestine, plasma, urine, liver, heart, kidney, skeletal muscle) at different time points (30 min, 2, 4, 24 hours).
Main Results:
- Significant absorption of the labeled enzyme mixture from the gastrointestinal tract was confirmed.
- Demonstrable radioactivity was found in plasma, urine, heart, kidney, liver, and skeletal muscle.
- Enzymes were distributed systemically after oral intake.
Conclusions:
- The oral enzyme preparation Wobenzym is absorbed from the intestine into the bloodstream.
- Absorbed enzymes are distributed to various organs and tissues in the body.
- This study supports the systemic availability of oral enzyme supplements.