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Influenza and infant mortality.

G W Griffith, A M Adelstein, P M Lambert

    British Medical Journal
    |September 2, 1972
    PubMed
    Summary

    Early neonatal mortality rose in England and Wales following a 1970 influenza epidemic. This trend mirrored previous epidemics, suggesting a link between influenza and increased infant deaths, possibly due to prematurity.

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    Area of Science:

    • Epidemiology
    • Public Health
    • Neonatal Care

    Background:

    • Major influenza epidemics can impact public health outcomes.
    • Neonatal mortality rates are sensitive indicators of population health.
    • Historical data analysis is crucial for understanding disease impact.

    Purpose of the Study:

    • To investigate the relationship between influenza epidemics and early neonatal mortality.
    • To analyze trends in infant mortality in relation to influenza prevalence over 25 years.
    • To identify potential causes for increased neonatal mortality post-epidemic.

    Main Methods:

    • Comparative analysis of neonatal mortality data from England and Wales.
    • Statistical analysis of infant mortality rates and influenza prevalence index.
    • Examination of historical epidemic data over a quarter-century.

    Main Results:

    • A significant increase in early neonatal mortality was observed in Q1 and Q2 of 1970, following an influenza epidemic.
    • Similar mortality increases were associated with four of the five major influenza epidemics studied.
    • The "Asian flu" epidemic of 1957 was an exception, showing no corresponding rise in mortality.
    • Increased prematurity rate is suggested as a potential cause for the observed mortality increase.

    Conclusions:

    • Influenza epidemics are associated with increased early neonatal mortality in England and Wales.
    • The observed effect may be linked to an increased prematurity rate.
    • Further research is needed to determine if the effect is virus-specific or non-specific.

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