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Related Experiment Videos

An enteroglucagon tumour.

S R Bloom

    Gut
    |July 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified the first enteroglucagonoma, a renal tumor secreting enteroglucagon. This hormone significantly impacts small bowel function, structure, and motility.

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    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Oncology

    Background:

    • A previously described renal tumor affected small bowel structure, motility, and function.
    • The tumor was noted to secrete a substance with glucagon-like immunoreactivity.

    Purpose of the Study:

    • To characterize the hormone secreted by the renal tumor.
    • To determine if the secreted hormone was enteroglucagon.

    Main Methods:

    • Extraction of the hormone from the renal tumor.
    • Analysis of molecular weight.
    • In vivo studies on plasma insulin and glucose.
    • Immunological reaction testing.

    Main Results:

    • The extracted substance showed molecular weight consistent with enteroglucagon.
  • The substance demonstrated in vivo effects on plasma insulin and glucose similar to enteroglucagon.
  • Immunological reactions confirmed the substance as enteroglucagon.

    • Conclusions:

    • The renal tumor is an enteroglucagonoma, the first reported case.
    • The tumor secretes enteroglucagon, a gut hormone impacting small bowel function.