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Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes
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Published on: December 27, 2014

Human blood monocytes: stimulators of granulocyte and mononuclear colony formation in vitro

P A Chervenick, A F LoBuglio

    Science (New York, N.Y.)
    |October 13, 1972
    PubMed

    Human blood monocytes in a feeder layer or by use for conditioning medium produced a colony-stimulating factor capable of stimulating the in vitro growth of colonies of granulocytes and mononuclear cells from human and murine marrow. Lymphocytes and neutrophils did not stimulate colony formation, and medium conditioned by neutrophils was inhibitory. This suggests that the monocyte may control granulocyte proliferation and maturation.

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