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Related Experiment Videos

The 'CREST' syndrome. Comparison with systemic sclerosis (scleroderma).

E E Velayos, A T Masi, M B Stevens

    Archives of Internal Medicine
    |November 1, 1979
    PubMed
    Summary

    CREST syndrome, a variant of systemic sclerosis, shares many features with scleroderma but presents with significantly less joint pain and inflammation. This highlights its unique position within the systemic sclerosis spectrum.

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    Area of Science:

    • Rheumatology
    • Dermatology
    • Internal Medicine

    Background:

    • CREST syndrome (Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, Telangiectasia) is a condition related to systemic sclerosis.
    • Understanding the relationship between CREST syndrome and systemic sclerosis is crucial for diagnosis and management.

    Observation:

    • A study compared 13 CREST patients with 26 systemic sclerosis patients lacking full CREST criteria.
    • Key clinical features like Raynaud's phenomenon, digital changes, and esophageal issues showed no significant differences between groups.
    • Laboratory findings, including elevated ESR, were also similar across both groups.

    Findings:

    • CREST patients exhibited significantly lower frequencies of arthralgia (54%) and arthritis (15%) compared to systemic sclerosis patients (88% and 65%, respectively).

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  • CREST syndrome predominantly affected women (all but one patient) and was exclusively observed in white individuals.
  • Most CREST patients presented with severe acrosclerosis, indicating a significant impact on their health.

    • Implications:

    • CREST syndrome and CRST syndrome appear to be closely related and part of the systemic sclerosis spectrum.
    • The distinct presentation of joint symptoms in CREST syndrome warrants further investigation within the broader context of systemic sclerosis.
    • These findings aid in differentiating and understanding the spectrum of systemic sclerosis and its variants.