Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.0K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

5.7K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.7K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
What is the Skeletal System?01:02

What is the Skeletal System?

56.2K
Overview
56.2K
Introduction to Electrolytes01:33

Introduction to Electrolytes

14.8K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
14.8K
The Bone Matrix01:18

The Bone Matrix

5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Investigation on the Persistence of Uranium Hydride during Storage of Simulant Nuclear Waste Packages.

PloS one·2015
Same author

Point-source beta irradiation of bone.

ANL·2014
Same author

The in vivo distribution of tetracyclines in canine bone.

The Journal of bone and joint surgery. American volume·2009
Same author

Long-term outcome of surgically-treated habitual patellar dislocation in children with coexistent patella alta. Minimum follow-up of 11 years.

The Journal of bone and joint surgery. British volume·2007
Same author

Prevention of venous thromboembolism after knee arthroplasty. A randomized, double-blind trial comparing enoxaparin with warfarin.

Annals of internal medicine·1996
Same author

[Efficacy and safety of prophylactic preoperative administration of low-dose warfarin in cemented total knee prostheses].

Annales de chirurgie·1994
Same journal

Extracellular matrix reprogramming by the YAP/TAZ- TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models.

The Journal of clinical investigation·2026
Same journal

Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer.

The Journal of clinical investigation·2026
Same journal

Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

The Journal of clinical investigation·2026
Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026
Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026
Same journal

MDM2 degraders for Merkel cell carcinoma: round peg in a round hole.

The Journal of clinical investigation·2026
See all related articles

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
06:16

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

1.1K

Bone and soft tissue changes with oral phosphate supplements.

G H Laflamme, J Jowsey

    The Journal of Clinical Investigation
    |November 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Oral phosphate supplements in adult dogs led to bone loss and soft tissue calcification. This occurred due to increased bone resorption and secondary hyperparathyroidism, despite stable serum calcium levels.

    More Related Videos

    Accessing the Cytotoxicity and Cell Response to Biomaterials
    09:46

    Accessing the Cytotoxicity and Cell Response to Biomaterials

    Published on: July 8, 2021

    4.4K
    Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
    14:55

    Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

    Published on: June 24, 2018

    9.6K

    Related Experiment Videos

    Last Updated: Dec 20, 2025

    Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
    06:16

    Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

    Published on: April 26, 2024

    1.1K
    Accessing the Cytotoxicity and Cell Response to Biomaterials
    09:46

    Accessing the Cytotoxicity and Cell Response to Biomaterials

    Published on: July 8, 2021

    4.4K
    Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
    14:55

    Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

    Published on: June 24, 2018

    9.6K

    Area of Science:

    • Veterinary Medicine
    • Bone Metabolism
    • Mineral Homeostasis

    Background:

    • Phosphate is essential for bone health and cellular function.
    • Excessive phosphate intake can disrupt mineral balance.
    • The effects of long-term oral phosphate supplementation in adult dogs are not well-established.

    Purpose of the Study:

    • To investigate the effects of oral phosphate supplementation on bone density, bone turnover, and soft tissue calcification in adult dogs.
    • To assess changes in serum calcium, phosphate, and parathyroid hormone levels.
    • To determine the impact on calcium deposition in various soft tissues.

    Main Methods:

    • Adult dogs received oral phosphate supplements for 10 months.
    • Bone density and turnover were assessed using bone samples.
    • Serum chemistry, including calcium, phosphate, and parathyroid hormone, was analyzed.
    • Histological examination evaluated soft tissue calcification.

    Main Results:

    • Serum calcium levels remained stable, while serum phosphate decreased slightly.
    • Increased bone resorption was observed in ulna and iliac crest samples.
    • Serum parathyroid hormone increased, indicating secondary hyperparathyroidism.
    • Histological evidence of soft tissue calcification was found in the kidney and eye lens (cataracts).
    • Increased calcium content was noted in the aorta, kidney, heart, and tendon.

    Conclusions:

    • Oral phosphate supplementation in adult dogs can lead to significant bone loss.
    • The supplementation induced secondary hyperparathyroidism and altered bone turnover.
    • Soft tissue calcification, particularly in the kidney and eye, is a notable consequence.
    • These findings suggest potential risks associated with long-term oral phosphate supplementation in canines.