Related Experiment Video
Updated: Jul 21, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy
Abstract:
Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Other Disorders of Digestive System
Type I Diabetes I: Introduction
Inflammatory Bowel Disease III: Crohn's Disease

