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Related Experiment Videos

Hemolytic ghost cell glaucoma. Further studies.

D G Campbell, E M Essigmann

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    Ghost cell glaucoma, a rare complication after cataract surgery, occurs when red blood cell (RBC) ghosts obstruct aqueous outflow. This study details its variations and pathogenesis, distinguishing it from other glaucoma types.

    Area of Science:

    • Ophthalmology
    • Pathology

    Background:

    • Ghost cell glaucoma is a rare complication following cataract extraction.
    • It is characterized by obstruction of aqueous humor outflow channels.

    Purpose of the Study:

    • To present three variations of ghost cell glaucoma after cataract surgery.
    • To elucidate the pathogenesis of this condition.
    • To differentiate it from other forms of glaucoma.

    Main Methods:

    • Clinical case presentations.
    • Ultramicroscopy of aqueous specimens.
    • Scanning and transmission electron microscopy of vitreous.
    • Perfusion studies.

    Main Results:

    • The most common variant involves anterior chamber and vitreous hemorrhage post-surgery.

    Related Experiment Videos

  • Red blood cell (RBC) ghosts form in the vitreous and obstruct outflow channels as hemorrhage clears.
  • Ultramicroscopy confirmed RBC ghosts as the primary cause, distinct from macrophages or RBC debris.
  • Electron microscopy revealed RBCs disintegrating into ghosts and denatured hemoglobin aggregates within vitreous strands.
  • Perfusion studies indicated an intact anterior hyaloid face prevents passage of RBCs and ghosts.

    • Conclusions:

    • Ghost cell glaucoma following cataract extraction is caused by obstructed aqueous outflow by RBC ghosts.
    • The integrity of the anterior hyaloid face is crucial in preventing ghost cell migration.
    • Understanding the pathogenesis aids in distinguishing ghost cell glaucoma from other glaucoma types.