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Updated: Aug 7, 2026

An Isolated Working Heart System for Large Animal Models
Published on: June 11, 2014
Clinical and physiological findings when the cardiac contraction is incoordinate compared with those found in matched
Insights
Cardiac incoordination, indicated by multiple tests, is linked to severe coronary heart disease. Patients with incoordination experienced more angina and poorer heart function, suggesting it appears late in the disease course.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Cardiac incoordination can be detected using multiple diagnostic tests.
- Coronary heart disease involves impaired blood supply to the heart muscle.
Purpose of the Study:
- To compare patients with and without cardiac incoordination.
- To identify physiological markers associated with cardiac incoordination.
Main Methods:
- Comparison of two patient groups: one with cardiac incoordination, one with coordinated heartbeat.
- Utilized electrocardiogram (ECG), pulse derivative, and ventriculogram for assessment.
- Paired case analysis to control for confounding variables.
Main Results:
- Patients with cardiac incoordination exhibited significantly higher rates of angina pectoris.
- Coronary arteriosclerosis and abnormal electrocardiograms were more prevalent in the incoordination group.
- A smaller ejection fraction and slower pulse rate were observed in patients with cardiac incoordination.
Conclusions:
- Cardiac incoordination is associated with severe coronary heart disease.
- It may represent a late-stage consequence of interrupted coronary blood flow.
- Physiological functions, apart from cardiac performance, showed no significant differences.
Abstract:
A group of patients in whom the Bcg, the pulse derivative and the ventriculogram all agreed that cardiac incoordination was present has been compared with another group in which the same three tests agreed that the heartbeat was well coordinated. By pairing the cases we have demonstrated that those with cardiac incoordination showed significantly more angina pectoris, more coronary arteriosclerosis, more abnormal electrocardiograms, a slowed pulse rate and a smaller ejection fraction than did the corresponding cases. The other physiological functions measured were not significantly different in the two groups. Evidently, incoordination of the cardiac contraction is associated with other evidences of severe coronary heart disease. One can regard it as the physiological consequences of the irregular interruptions of coronary blood supply which characterize the pathological anatomy of this disease, and can expect it to appear late in its course.
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