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Hemoglobin Beta chain structural variation in mice: evolutionary and functional implications.

J G Gilman

    Science (New York, N.Y.)
    |November 24, 1972
    PubMed
    Summary
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    The mouse hemoglobin beta chain locus (Hbb(d)) has two genes, betamin and betadmaj. Mus caroli possesses a single beta chain, potentially a Lepore type, suggesting evolutionary selection shaped mouse beta-globin genes.

    Area of Science:

    • Genetics and Genomics
    • Molecular Evolution
    • Comparative Genomics

    Background:

    • The Hbb(d) allele in Mus musculus contains two distinct, linked beta-globin genes: betamin and betadmaj.
    • Mus caroli exhibits a single beta-globin gene with characteristics of both betamin and betadmaj.

    Purpose of the Study:

    • To investigate the evolutionary relationships of mouse beta-globin genes.
    • To characterize the beta-globin gene in Mus caroli and compare it to Mus musculus.

    Main Methods:

    • Comparative sequence analysis of beta-globin genes.
    • Bioinformatic analysis of gene structure and evolutionary pressures.

    Main Results:

    • Mus caroli's single beta-globin gene shows a mosaic structure, resembling a Lepore-type globin.

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  • Sequence data indicate potential functional constraints and evolutionary selection acting on mouse beta-globin genes.

    • Conclusions:

    • The beta-globin gene evolution in mice may have been driven by selection.
    • The unique structure of the Mus caroli beta-globin suggests a distinct evolutionary path or functional adaptation.