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Summary
Granuloma venereum, a sexually transmitted infection, was identified in six African females in Zambia. One case mimicked cervical cancer, highlighting diagnostic challenges without histological confirmation.
Area of Science:
- Medical Microbiology
- Dermatology
- Gynecologic Oncology
Background:
- Granuloma venereum (GV) is a chronic bacterial infection caused by *Donovania granulomatis*.
- GV is endemic in many tropical and subtropical regions worldwide.
- Despite its endemicity, GV has not been previously reported in Zambia.
Purpose of the Study:
- To report the first cases of granuloma venereum diagnosed in Zambia.
- To highlight an unusual presentation of GV involving the cervix.
- To emphasize the diagnostic difficulties and potential misdiagnosis of GV as malignancy.
Main Methods:
- Retrospective review of biopsy specimens from six female patients.
- Histopathological examination of tissue samples.
- Clinical correlation of findings.
Main Results:
- Six cases of granuloma venereum were confirmed via biopsy in African females.
- One case presented with primary cervical involvement, clinically resembling cervical carcinoma.
- Histological confirmation was crucial for accurate diagnosis, differentiating GV from malignancy.
Conclusions:
- Granuloma venereum is present in Zambia, challenging previous geographical assumptions.
- The cervical manifestation of GV can mimic cervical cancer, underscoring the need for histological diagnosis.
- Early and accurate diagnosis of granuloma venereum is essential to prevent misdiagnosis and ensure appropriate treatment.