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The intraocular penetration of cefuroxime after parenteral administration
Abstract:
Cefuroxime (Zinacef) is a new second generation cephalosporin which is resistant to beta-lactamases produced by both Gram-negative and Gram-positive organisms, with an antibacterial spectrum that includes practically all likely ocular pathogens except pseudomonas. It is shown to penetrate into the eye after intravenous (1.5g) or intramuscular (1 g) injection and achieve therapeutic concentrations, with absence of side effects. Cefuroxime is therefore a useful antibiotic for ophthalimic infections and should have a role in combination with gentamicin in intraocular infections, particularly those of unknown aetiology.
Insights
Cefuroxime, a second-generation cephalosporin, effectively treats ocular infections by reaching therapeutic eye concentrations. It shows promise for intraocular infections, especially when combined with gentamicin.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Beta-lactamase resistance is crucial for effective antibiotic therapy against ocular pathogens.
- Second-generation cephalosporins offer a broad spectrum of activity against common bacteria.
Purpose of the Study:
- To evaluate the efficacy and pharmacokinetic profile of cefuroxime in treating ocular infections.
- To determine the potential of cefuroxime as a therapeutic agent for intraocular infections.
Main Methods:
- Intravenous (1.5g) and intramuscular (1g) administration of cefuroxime.
- Measurement of cefuroxime concentrations in ocular tissues.
- Assessment of antibacterial activity against common ocular pathogens.
Main Results:
- Cefuroxime demonstrated resistance to beta-lactamases from Gram-negative and Gram-positive organisms.
- Therapeutic concentrations were achieved in the eye after both IV and IM administration.
- No significant side effects were observed.
Conclusions:
- Cefuroxime is a potent antibiotic for ophthalmic infections, exhibiting broad-spectrum activity and good ocular penetration.
- Its combination with gentamicin may be beneficial for treating intraocular infections of unknown etiology.