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Systemic absorption of topically applied chloramphenicol eyedrops
The British Journal of Ophthalmology
|October 1, 1979
Summary
Topical chloramphenicol eye drops in young children showed no systemic absorption. This study assesses the safety of this common ophthalmic antibiotic in pediatric patients.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Pharmacology
Background:
- Topical chloramphenicol is frequently used for pediatric eye infections.
- Concerns exist regarding potential systemic absorption and associated risks in children.
Purpose of the Study:
- To evaluate systemic absorption of topical chloramphenicol in children under 9 years old.
- To discuss the safety profile and literature regarding pediatric use.
Main Methods:
- Five children under 9 received topical chloramphenicol eye drops every 2 hours for 5-7 days.
- Systemic drug levels were measured using two sensitive assays.
Main Results:
- No detectable systemic absorption of chloramphenicol was found in any of the children studied.
- The drug was administered for a duration of 5 to 7 days.
Conclusions:
- Topical chloramphenicol administration appears safe regarding systemic absorption in young children.
- Further discussion on the drug's hazards and existing literature is warranted.