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Primary structure of the human chorionic somatomammotropin (HCS) molecule
Science (New York, N.Y.)
|July 2, 1971
Summary
The amino acid sequence for human chorionic somatomammotropin was determined. This sequence was then compared to human growth hormone and ovine lactogenic hormone.
Area of Science:
- Biochemistry
- Endocrinology
- Molecular Biology
Background:
- Human chorionic somatomammotropin (hCS) is a placental hormone with structural similarities to pituitary hormones.
- Understanding the primary structure of hCS is crucial for elucidating its function and evolutionary relationships.
Purpose of the Study:
- To propose the complete amino acid sequence of the human chorionic somatomammotropin molecule.
- To compare the proposed hCS sequence with those of human growth hormone (hGH) and ovine lactogenic hormone (oLG).
Main Methods:
- Sequence analysis and comparison of homologous proteins.
- Utilizing established protein sequencing methodologies.
Main Results:
- The complete amino acid sequence of human chorionic somatomammotropin has been proposed.
- Comparative analysis revealed sequence similarities and differences between hCS, hGH, and oLG.
Conclusions:
- The proposed amino acid sequence provides a foundation for further functional studies of hCS.
- Sequence comparison aids in understanding the structural basis for the shared and distinct biological activities of these related hormones.