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Is appendicitis familial?

N Andersson, H Griffiths, J Murphy

    British Medical Journal
    |September 22, 1979
    PubMed
    Summary
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    A family history of appendicectomy is more common in children with acute appendicitis. This suggests a genetic link, indicating a familial predisposition to developing appendicitis.

    Area of Science:

    • Medical research
    • Genetics
    • Gastroenterology

    Background:

    • Appendicitis is a common surgical emergency.
    • The etiology of appendicitis is not fully understood.
    • Familial aggregation of diseases can suggest genetic factors.

    Purpose of the Study:

    • To investigate the potential familial predisposition to acute appendicitis in children.
    • To determine if a family history of appendicectomy is more prevalent in children with appendicitis.

    Main Methods:

    • A case-control study was conducted involving children admitted to Llandough Hospital.
    • The study included 29 children with confirmed acute appendicitis (study group) and 29 children admitted for other reasons (control group).
    • Family history of appendicectomy in first-degree relatives (parents, siblings) was collected for both groups.

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    Main Results:

    • A family history of appendicectomy was reported in 20 out of 29 children in the study group.
    • Only four out of 29 children in the control group reported a family history of appendicectomy.
    • This difference was statistically significant, suggesting a link between family history and appendicitis.

    Conclusions:

    • The findings suggest a familial predisposition to acute appendicitis.
    • Genetic factors may play a role in the development of appendicitis.
    • Further research into the genetic basis of appendicitis is warranted.