[Radiotherapy of inoperable orofacial squamous epithelial carcinomas following pharmacologically induced partial...

A therapeutical method of inoperable squamous cell carcinomas based on cell kinetics has been applied since 1969 by using 5-fluorine-uracil. Impulse cytophotometric tests did not confirm the degree of partial synchronization due to 5FU that had been assumed so far on the basis of autoradiographic techniques. The results obtained in 46 patients with inoperable malignant epithelial tumors of the maxillo-facial region that were better than those obtained with radiological therapy only, can to a certain extent be contributed to 5FU. First impulse cytophotometric findings in biopsies of animal and human tumors show that Bleomycin clearly produced partial synchronization due to a reversible stop in the radiation-sensitive G2 phase.